NMC

Vacancies

The Netherlands Metabolomics Centre is a unique, multidisciplinary combination of pioneering experts dedicated to develop metabolomics technologies and to incorporate the emerging tools into biological/biomedical research through collaborations with academic groups, clinical centres and industry.

The mission of NMC is to take the lead in the creation of a world-class metabolomics knowledge infrastructure to improve personal health. The NMC has recently been founded by a subsidy from the Netherlands Genomics Initiative, and will have a budget of 50 M€ for the period from 2008-2012. The researchers will have a high degree of collaboration with each other, and will conduct their research at different places.

The NMC invites applications for the following positions:

Post-doctoral and PhD student positions in the following research areas:

Biostatistics

Biostatistics tools provide the link between quantified (and possibly identified) metabolites and biology. As such, it encompasses a broad area of tools.
vacancy for a Programmer data visualization

Project summaries for current Biostatistics projects

Quantitative Profiling:

For the acquisition of better quantitative data of hundreds of metabolites in biological samples, technology platforms are developed of validated and standardized protocols and methods for sampling, sample handling and quantitative analysis of relevant identified metabolites in volumes as small a few microlitres. Both in-depth profiling of metabolites as well as a more global or targeted profiling are considered. Some aims are of a broader nature and are integrated within several activities: high throughput is essential for applicability of metabolomics for the study of larger cohorts or for the cost-efficient application to industrial questions.

Project summaries for current Quantitative Profiling projects

Metabolite Identification

For the identification of metabolites a semi-automated enrichment and fractionation strategy using LCxLC-SPE, coupled to identification using cryoNMR/MS, either in on- of off-line mode is envisioned.
Better strategies for structure elucidation will be developed for NMR and MSⁿ data. For MSⁿ data, algorithms will be developed to obtain structural information from the fragmentation patterns in the mass spectrometer. Metabolites will be identified starting with possible structures for the elemental composition using databases KEGG, etc), confirmation/elimination of candidates by NMR information, physical and (bio)chemical constraints, and other additional information.

Examples of envisioned projects are:

Fractionation and enrichment strategies for LC-NMR/FTMSⁿ
Algorithm- and rule-based identification to identify structures by MSⁿ
Strategies for de-novo identification using NMR/MSⁿ and physical/(bio)chemical constraints
De-novo identification of metabolites with GC-EI-MSⁿ
Composition of (sub)metabolomes and specific metabolomes

Biomarkers in Endometriosis

A postdoctoral position is available immediately at the NMC.

Metabolomics in Nutrition & Health

Within the NMC Unilever, DSM and the NutriGenomics Consortium (NGC) collaborate to apply novel metabolomics approaches to resolve current bottlenecks in nutrition and health research

Project summaries for current Nutritional metabolomics projects

Demonstration and Competance lab

For the DCL laboratory we are looking for an LC-MS RESEARCH ANALIST Metabolomics, details can be found here.

The developed tools and methods will be applied and further optimized to answer challenging biological questions together with other researchers at Genomics Centres or the industry.

If you are interested, you are invited to submit your CV and a letter of motivation to info@metabolomicscentre.nl. Your CV will be accessible for the different consortium partners; in case of interest, you will be contacted.


About NMC Mission About NMC Metabolomics Organisation NGI Research Introduction Projects overview Core Themes Associate Projects Infrastructure Partners NMC Core Partners Vacancies Contact News & Events Links NMC Intranet

Vacancies The Netherlands Metabolomics Centre is a unique, multidisciplinary combination of pioneering experts dedicated to develop metabolomics technologies and to incorporate the emerging tools into biological/biomedical research through collaborations with academic groups, clinical centres and industry. The mission of NMC is to take the lead in the creation of a world-class metabolomics knowledge infrastructure to improve personal health. The NMC has recently been founded by a subsidy from the Netherlands Genomics Initiative, and will have a budget of 50 M€ for the period from 2008-2012. The researchers will have a high degree of collaboration with each other, and will conduct their research at different places. The NMC invites applications for the following positions: Post-doctoral and PhD student positions in the following research areas: Biostatistics Biostatistics tools provide the link between quantified (and possibly identified) metabolites and biology. As such, it encompasses a broad area of tools. vacancy for a Programmer data visualization Project summaries for current Biostatistics projects Quantitative Profiling: For the acquisition of better quantitative data of hundreds of metabolites in biological samples, technology platforms are developed of validated and standardized protocols and methods for sampling, sample handling and quantitative analysis of relevant identified metabolites in volumes as small a few microlitres. Both in-depth profiling of metabolites as well as a more global or targeted profiling are considered. Some aims are of a broader nature and are integrated within several activities: high throughput is essential for applicability of metabolomics for the study of larger cohorts or for the cost-efficient application to industrial questions. Project summaries for current Quantitative Profiling projects Metabolite Identification For the identification of metabolites a semi-automated enrichment and fractionation strategy using LCxLC-SPE, coupled to identification using cryoNMR/MS, either in on- of off-line mode is envisioned. Better strategies for structure elucidation will be developed for NMR and MSⁿ data. For MSⁿ data, algorithms will be developed to obtain structural information from the fragmentation patterns in the mass spectrometer. Metabolites will be identified starting with possible structures for the elemental composition using databases KEGG, etc), confirmation/elimination of candidates by NMR information, physical and (bio)chemical constraints, and other additional information. Examples of envisioned projects are: Fractionation and enrichment strategies for LC-NMR/FTMSⁿ Algorithm- and rule-based identification to identify structures by MSⁿ Strategies for de-novo identification using NMR/MSⁿ and physical/(bio)chemical constraints De-novo identification of metabolites with GC-EI-MSⁿ Composition of (sub)metabolomes and specific metabolomes Biomarkers in Endometriosis A postdoctoral position is available immediately at the NMC. Metabolomics in Nutrition & Health Within the NMC Unilever, DSM and the NutriGenomics Consortium (NGC) collaborate to apply novel metabolomics approaches to resolve current bottlenecks in nutrition and health research Project summaries for current Nutritional metabolomics projects Demonstration and Competance lab For the DCL laboratory we are looking for an LC-MS RESEARCH ANALIST Metabolomics, details can be found here. The developed tools and methods will be applied and further optimized to answer challenging biological questions together with other researchers at Genomics Centres or the industry. If you are interested, you are invited to submit your CV and a letter of motivation to info@metabolomicscentre.nl. Your CV will be accessible for the different consortium partners; in case of interest, you will be contacted.		Johan Westerhuis receives EAS Award 08 March 2010 Amsterdam Metabolomics 2010 - REGISTER NOW RAI Amsterdam, 27 June-1 July 2010 Announcement Spring meeting NVMS Vlaardingen, 11 March 2010 NBIC conference 2010 Lunteren, 29-30 March 2010 30th ISPPP - Call for Papers Bologna, Italy, 6-8 September 2010 NGI sponsors Postdoc Retreat The Hague, 21-23 April 2010 Patent workshop IOP genomics The Hague, 11 May 2010 Pre-Seed Grant NGI The Hague, January 2010 Metabolomics in Nature's vision 2020 Nature Magazine 7 January 2010 Metabolomics receives first ever Impact Factor Rating UK 17 August 2009 NMC makes the difference NMC, Leiden Puzzling with metabolites NMC, NBIC, May 2009 First NMC paper published Amsterdam, Utrecht, January 2009 Robert Hall elected as secretary Metabolomics Society 11 December 2008

Disclaimer